Pharmaceutics is concerned not only with the formulation of effective dosage forms, but also with the fate of an active ingredient after it enters the body. My research has included studies on the interaction of drugs with plasma proteins and methods for examining such interactions. The effect of an artificial (perfluorochemical) blood substitute on the binding of various drugs by plasma proteins have also been studied. Improvement in aqueous drug solubility and, therefore, bioavailability through complexation with cyclodextrans have also been studied. Current efforts are heavily directed towards the development of effective and stable oral dosage forms, primarily tablets. Selected Publications I.G. Shah and D.L. Parsons, "Preparation and In Vitro Evaluation of Powder Solution Tablets of Valproic Acid," Drug Dev. Ind. Pharm., 19, 1587 1602 (1993). L. Zhang, D.L. Parsons, C. Navarre and U.B. Kompella, "Development and In Vitro Evaluation of Sustained Release Poloxamer 407 (P407) Gel Formulations of Ceftiofur," J.Control.Rel., 85, 73 81 (2002).