Our group studies the Epidermal Growth Factor (EGF) family of peptide hormones and their receptors, the ErbB family of receptor tyrosine kinases. This network plays significant roles in regulating the proliferation and differentiation of epithelial cells. Moreover, deregulated signaling by this network is a causative event in many human tumors, and contributes to increased tumor cell invasiveness, metastatic potential, and chemoresistance. Consequently, our group studies this signaling network with the ultimate goal being the development of novel cancer diagnostic and treatment strategies. Selected Publications J Foley, NK Nickerson, S Nam, KT Allen, JL Gilmore, KP Nephew, and DJ Riese II. EGFR signaling in breast cancer: Bad to the bone? Sem Cell Dev Biol 21: 951-960 (2010). PMID: 20813200. PMCID: 2991402. http://tinyurl.com/66xttg2 CP Mill, K Gettinger, and DJ Riese II. Ligand stimulation of ErbB4 and a constitutively-active ErbB4 mutant result in different biological responses in human pancreatic tumor cell lines. Exp Cell Res 317: 392-404 (2011). PMID: 21110957. PMCID: 3022118. http://tinyurl.com/63xebh5 DJ Riese II. Ligand-based receptor tyrosine kinase partial agonists: New paradigm for cancer drug discovery? Expert Opin Drug Disc 6: 185-193 (2011). PMID: 21532939. PMCID: 3083243. http://tinyurl.com/65jhomr MD Zordan, CP Mill, DJ Riese II, and JF Leary. A high-throughput, interactive imaging, bright-field wound healing assay. Cytometry A 79A: 227-232 (2011). PMID: 22045642. Free PMC Article. http://tinyurl.com/47ur49r CP Mill, MD Zordan, SM Rothenberg, J Settleman, JF Leary, and DJ Riese II. ErbB2 is necessary for ErbB4 ligands to stimulate oncogenic activities in models of human breast cancer. Genes & Cancer 2: 792-804 (2011). PMID: 22393464. Free PMC Article. http://tinyurl.com/7tbr684 KJ Wilson, CP Mill, S Lambert, J Buchman, TR Wilson, V Hernandez-Gordillo, RM Gallo, Laura MC Ades, J Settleman, and DJ Riese II. EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. Growth Factors 30: 107-116 (2012). PMID: 22260327. PMCID: N/A. http://tinyurl.com/d2ua4wf KJ Wilson, CP Mill, RM Gallo, EM Cameron, H VanBrocklin, J Settleman, and DJ Riese II. The Q43L mutant of Neuregulin 2beta is a pan-ErbB receptor antagonist. Biochem J 443: 133-144 (2012). PMID: 22216880. PMCID: N/A. http://tinyurl.com/6og7coh J Foley, NK Nickerson, DJ Riese II, PC Hollenhorst, G. Lorch, and AM Foley. At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of the bone. Odontology 100: 109-129 (2012). PMID: 22684584. PMCID: N/A. http://tinyurl.com/d8mxuoo