Graduate Student Directory

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Bio

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Education:

• B.S., Biology – Auburn University, 2019
• M.S. Pharmaceutical Science - Auburn University, 2023

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Research Areas:

• Cancer therapy
• Pharmacogenomics and single-cell omics
• Network alterations, hyperexcitability, and glutamate dysregulation
• Alzheimer’s disease

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Jeremiah Pfitzer is pursuing his Ph.D. in Pharmaceutical Science at the Harrison College of Pharmacy at Auburn University. His current research includes several drug development projects investigating novel secondary therapeutics in refractory/relapsed multiple myeloma. He is also spearheading a collaborative RAS driver mutations drug discovery project in multiple myeloma. He previously worked in targeting glutamate dysregulation in Alzheimer's disease and in discovering mechanisms driving tauopathies. He is also an assistant conference developer for the annual Innovations in SoTL Medical Education conference and has mentored over 25 students ranging from PYDI 4980 undergraduate research to the First Year Experience graduate student mentorship program.

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Publications

• Pfitzer JC, Pinky PD, Perman S, Redmon E, Cmelak L, Suppiramaniam V, Coric V, Querishi IA, Gramlich MW, Reed MN. Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice. J Neurochem; August 2024.
• Chakrabortty A, Kumar H, Pfitzer JC, Sharma N, Waliagha R, Mukherjee U, Kumar SK, Baughn LB, Ness BV, Mitra AK. Single-Cell Multi-Ome Analysis Reveals Novel Molecular Mechanisms Underlying Subclonal Response to Survivin Inhibition in Relapsed/Refractory Multiple Myeloma. Blood; November 2023.
• Ness BV, Mitra AK, Wiesen L, Baughn LB, Kumar SK, Petit J, Pfizer JC, Gyotoku K, Mutant N- and K-Ras Show Distinct Effects on Growth, Signaling and Drug Response in CRISPR-Cas Edited Alleles of a Myeloma Cell Line. Blood; November 2023.
• Priyanka PD, Bloemer J, Smith WD, Du Y, Heslin RT, Setti SA, Pfitzer JC, Chowdurry K, Hong H, Bhattacharya S, Dhanasekaran M, Ditayev A, Reed MN, Suppiramaniam V. Prenatal Cannabinoid Exposure Elicits Memory Deficits Associated with Reduced PSA-NCAM Expression, Altered Glutamatergic Signaling, and Adaptations in Hippocampal Synaptic Plasticity Cells; October 2023.
• Cotter R, Hellums M, Gray D, Batista D, Pfitzer JC, Reed MN, Gramich MW. Mitochondria Exhibit Changes in Morphology/Function to Support Increased Glutamate Release in TauP301L Neurons Prior to Reduction in Presynaptic Vesicle Release. iScience; July 2023.
• Taipla E, Pfitzer JC, Hellums M, Reed M.N., Gramlich M.W., rTg(TauP301L)4510 mice exhibit increased VGlut1 in hippocampal presynaptic glutamatergic vesicles and increased extracellular glutamate release. Frontiers in Synaptic Neuroscience; August 2022.
• Pinky PD, Pfitzer JC, Senfeld J, Hong H, Bhattacharya S, Suppiramaniam V, Quereshi I, Reed MN. Recent Insights on glutamatergic dysfunction in Alzheimer’s disease and therapeutic implications. The Neuroscientist; February 2022
• Hunsberger H, Setti SA, Rudy C, Weitzner D, Pfitzer JC, McDonald K, Hong H, Bhattacharya S, Suppiramaniam V, Reed MN. Differential effects of human P301L tau expression in young versus aged mice. Int. J. Mol. Sci. 2021, 22(21), 11637
• Dogan M, Setti SA, Pfitzer JC, Reed MN. Investigating the role of the lateral entorhinal cortex in Alzheimer’s disease. Auburn University Journal of Undergraduate Research; 2020