Graduate Student Directory

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Bio

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Education:

• B.Sc., Pharmacy - Jordan University of Science and Technology, 2012
• M.Sc., Clinical Pharmacy - Jordan University of Science and Technology, 2018

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Research Areas:

• Experimental Therapeutics, Pharmacokinetic and Pharmacokinetics in silico modeling, Identification of novel therapeutic targets devoted to finding therapies for neurodegenerative diseases, specifically Alzheimer’s disease and cerebral amyloid angiopathy.

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Coming from Irbid, Jordan. Nour Fadel M. Al-Ghraiybah joined Jordan University of Science and Technology in 2012 to pursue a bachelor’s in pharmacy where she graduated with honors in 2017. After her pharmacy degree, she joined MSc. Program in clinical pharmacy with emphasis in pharmacokinetics at Jordan University of Science and Technology. Her MSc program implements patient-focused clinical training in hospitals that enriched her experience as a pharmacist and scientist. Her MSc thesis work focused on studying the effect of preservatives as drug excipients (parabens) on drug transporters (p-glycoprotein) in rats and was published under the title “Evaluation of the effect of parabens on p-glycoprotein activity: a pharmacokinetic study.” Her master's project provided her with great experiences related to animal work, molecular biology, and analytical and pharmacokinetic analysis. After Her MSc, she worked as a research assistant for two years, working on various in-vivo and in-vitro projects.

Currently, she is a graduate student at the Harrison College of Pharmacy, pursuing a Ph.D. in Pharmaceutical Sciences. She started my journey as a Ph.D. graduate student in Dr. Amal Kaddoumi’s lab in Spring 2022. Her research focuses on developing therapeutic strategies targeting the blood-brain barrier function as a novel approach to prevent, slow down, and/or treat Alzheimer’s disease and related dementias.

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Publications

• Alshogran, O.Y; Al-Ghraiybah, N.F;  and Al-Azzam S.I.; Evaluation of the Effect of Isobutyl Paraben and 2-ethyl Hexyl Paraben on P-glycoprotein Functional Expression in Rats: A Pharmacokinetic Study, Current Molecular Pharmacology 2022; 15 (7): e270122200592.
• Al-Ghraiybah, N.F.; Wang, J.; Alkhalifa, A.E.; Roberts, A.B.; Raj, R.; Yang, E.; Kaddoumi, A. Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease. Int. J. Mol. Sci. 2022, 23, 10572.
• Alkhalifa, A.E.; Al-Ghraiybah, N.F.; Odum, J.; Shunnarah, J.G.; Austin, N.; Kaddoumi, A. Blood–Brain Barrier Breakdown in Alzheimer’s Disease: Mechanisms and Targeted Strategies. Int. J. Mol. Sci. 2023, 24, 16288.
• Abdallah, I.M.; Al-Shami, K.M.; Alkhalifa, A.E.; Al-Ghraiybah, N.F.; Guillaume, C.; Kaddoumi, A. Comparison of Oleocanthal-Low EVOO and Oleocanthal against Amyloid-β and Related Pathology in a Mouse Model of Alzheimer’s Disease. Molecules 2023, 28, 1249.
• Nuseir, K., Alzoubi, K. H., Altarifi, A., Kassab, M., Khabour, O. F., Al-Ghraiybah, N. F., & Obiedat, R. Long-term effects of neonatal pain and sucrose treatment 2024, Current research in pharmacology and drug discovery, 6, 100176.
• Alkhalifa, A.E.; Al-Ghraiybah, N.F.; Kaddoumi, A. Extra-Virgin Olive Oil in Alzheimer’s Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies. Int. J. Mol. Sci. 2024, 25, 1914.
• Al Rihani, S. B., Elfakhri, K. H., Ebrahim, H. Y., Al-Ghraiybah, N. F., Alkhalifa, A. E., El Sayed, K. A., & Kaddoumi, A. The Usnic Acid Analogue 4-FPBUA Enhances the Blood–Brain Barrier Function and Induces Autophagy in Alzheimer’s Disease Mouse Models. ACS Chemical Neuroscience. 2024, 10.1021/acschemneuro.4c00326. Advance online publication.

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